Evaluating the Green Credentials of Flow Chemistry towards Industrial Applications

Continuous flow chemistry is becoming an established technology platform that finds frequent application in industrial chemical manufacture with support and endorsements by the FDA for pharmaceuticals. Amongst the various advantages that are commonly cited for flow chemistry over batch processing, sustainability continues to require further advances and joint efforts by chemists and chemical engineers in both academia and industry. This short review highlights developments within the last 5 years that positively impact on the green credentials associated with flow chemistry, specifically when applied to the preparation of pharmaceuticals. An industrial perspective on current challenges is provided to whet discussion and stimulate further investment towards achieving greener modern synthetic technologies.

Evaluating the Green Credentials of Flow Chemistry towards Industrial Applications, Marcus Baumann, Thomas S. Moody, Megan Smyth and Scott Wharry, Synthesis, 2021, DOI: 10.1055/a-1541-1761