Predictive assay for anti-angiogenic agents (AADx) identifies a molecular subgroup of RAS wt mCRC with low efficacy of FOLFIRI plus bevacizumab – analysis of the FIRE-3 (AIO KRK-0306) trial

The data suggests that the AADx assay interacts with RAS mutation and may define RAS wild-type mCRC patients that respond differently to cetuximab or bevacizumab in combination with FOLFIRI. One potential explanation of the data is that Cetuximab is a more effective treatment for the poor prognosis ANGIO ON subtype.