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Development and Scale-Up of an Antibody Drug Conjugate Tubulysin Payload

Read how significant development and scale-up work was completed on the synthesis of an antibody drug conjugate payload based on the tubulysin natural products.
This work included the development of new routes, as well as extensive optimzation of the solid phase peptide synthesis used to assemble the molecule. Find out how the initial route was improved to a new, more robust route, affording a 240-fold increase in overall yield and allowing delivery of over 86 g of the required molecule.

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