Platinum-based therapy selects for an angiogenic enriched tumor micro-environment in High Grade Serous Ovarian Cancer

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Conclusion:
1. The clinical and pre-clinical data discussed has potentially significant clinical implications in the management of treatment-relapsed HGSOC
2. Platinum-resistance (innate and acquired) in relapsed HGSOC is an indicator for response to anti-angiogenics
3. We have found that relapse post platinum-therapy in HGSOC is associated with an angiogenic biology
4. This clinical and pre-clinical data supports the use of anti-angiogenic agents in the first and second line setting in patients with innate and acquired resistance to platinum therapy, respectively